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KMID : 1132720190170010003
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Genomics & Informatics
2019 Volume.17 No. 1 p.3 ~ p.3
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Identification of ERBB Pathway-Activated Cells in Triple-Negative Breast Cancer
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Cho Soo-Young
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Abstract
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Intratumor heterogeneity within a single tumor mass is one of the hallmarks of malignancy and has been reported in various tumor types. The molecular characterization of intratumor heterogeneity in breast cancer is a significant challenge for effective treatment. Using single-cell RNA sequencing (RNA-seq) data from a public resource, an ERBB pathway activated triple-negative cell population was identified. The differential expression of three subtyping marker genes (ERBB2, ESR1, and PGR) was not changed in the bulk RNA-seq data, but the single-cell transcriptomes showed intratumor heterogeneity. This result shows that ERBB signaling is activated using an indirect route and that the molecular subtype is changed on a single-cell level. Our data propose a different view on breast cancer subtypes, clarifying much confusion in this field and contributing to precision medicine.
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KEYWORD
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breast neoplasms, ERBB signaling pathway, intratumor heterogeneity, molecular subtyping, single-cell RNA-seq
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